Understanding cell types and diseases

Understanding cell types and the progression of diseases

Based on the accessibility of chromatin, researchers can construct a spatial cell atlas.

Understanding cell types and the progression of diseases as the local environment affects how cells function in tissues. For a deeper understanding of the disease, mapping the molecular characteristics of cells. The development of spatial transcriptomics has made it possible to map gene expression at a genome-wide scale. However, there is still a deficiency in the ability to record the spatial epigenetic information of tissue at the cellular and genomic scales. The method for spatially resolved chromatin accessibility analysis of tissue sections has now been created by a team of Yale and Karolinska Institutet researchers.

The technique aims to better understand how diseases evolve and may aid in the creation of intricate molecular atlases of individual cells in various organs. The technique specifies which chromatin areas are accessible genome-wide in cells at particular sites in a tissue.

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 This chromatin accessibility is necessary for gene activation and provides unique information on the molecular health of any given cell. Understanding cell identity, cell state, and the underlying mechanisms that control the expression of genes—known as epigenetics.The development of different tissues or diseases has advanced.

Yale University’s Rong Fan:

Yale University’s Rong Fan, a professor of biomedical engineering. Now that we know the different cell kinds, we can create an atlas of spatial cells based on chromatin accessibility. 

This technique on brain tissue enables researchers to observe the detailed development of different brain areas. They also used it on human tonsil tissue to gain insight into the structure of immune cell types. It is an effective tool for creating cell atlases and maps. 

 They were able to identify the epigenome of several cell types in the mouse brain tissue using the novel method, according to Yanxiang Deng, a postdoctoral associate in Fan’s lab and the study’s primary author.

will give insights into the molecular mechanisms that mediate the acquisition of pathological cellular states. As said Goncalo Castelo-Branco, professor of glial cell biology at Karolinska Institutet.

 Source: techexplorist